1-Butanol → L-Cysteine, butyl ester, hydrochloride (1:1)

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Reaction Steps

L-Cysteine hydrochloride (100 g) is dissolved in 250 ml of butanol saturated with dry HCl. The solution is heated under reflux for 4 hours. Excess solvent is evaporated and ethyl acetate (150 ml) is added to the residue. The crystals which form are recrystallized from ethyl acetate, mp 91° C., yield 30%, IR (KBr)1745 cm-1 ; NMR (CDCl3) δ9.2-3.4 (b, 3, NH3⊕), 4.7 (t, 1, --CH), 4.3 (t, 2, --OCH2 --), 3.3 (b, 2, CH2S), 1.0 (5, 3, --CH3), 1.0-3.0 (m, 4, --CH2CH2).

Provenance & Evidence