Hydrochloric Acid → HCID 45263932, compound

Participants

Reaction Steps

820 mg of ethyl 5-chloroimidazo-[1,2-a]-quinoline-2-carboxylate were dissolved in 50 ml of ethanol and 6.6 ml of 0.5 N sodium hydroxide solution were added to the solution obtained. The resultant mixture was refluxed for 1 hour, then was cooled to room temperature and acidified to a pH of ~1 by addition of concentrated hydrochloric acid. The solvent was removed under vacuum and the residue was dissolved in methanol. The solution formed was filtered and the filtrate was reduced in volume under vacuum and then was cooled to obtain off-white crystals of 5-chloroimidazo-[1,2-a]-quinoline-2-carboxylic acid hydrochloride melting at 263°-265° C. (decomposition).

Provenance & Evidence