反应详情

1.3 g of 2-amino-4-chloro-7-methoxyquinoline were dissolved in 20 ml of dimethoxyethane and 1.3 g of ethyl bromopyruvate were added thereto. The mixture was stirred at room temperature for 2 hours and the crystalline intermediate thus formed was filtered off, washed with ether and then was dissolved in 20 ml of ethanol. The resultant solution was refluxed for 3 hours and ethyl 5-chloro-8-methoxyimidazo-[1,2-a]-quinoline-2-carboxylate melting at 215°-216° C. was isolated by the procedure of Example 9.

1. customthe crystalline intermediate thus formed
2. filtrationwas filtered off
3. washwashed with ether
4. dissolutionwas dissolved in 20 ml of ethanol
5. temperatureThe resultant solution was refluxed for 3 hours