HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5,8-Dichloroimidazo-[1,2-a]-quinoline-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,2-Dimethoxyethane | HCID 8071 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 5,8-dichloroimidazo-[1,2-a]-quinoline-2-carboxylate | HCID 12763976 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5,8-Dichloroimidazo-[1,2-a]-quinoline-2-carboxylic acid | HCID 12763975 | — |
Reaction Steps
1.24 g of ethyl 5,8-dichloroimidazo-[1,2-a]-quinoline-2-carboxylate were hydrolyzed with 3 ml of 2 N sodium hydroxide solution in 120 ml of 50--50 mixture of dimethoxyethane and ethanol. The resultant mixture was neutralized with 3.3 ml of 2 N hydrochloric acid by the method of Example 20 to obtain fine off-white crystals of 5,8-dichloroimidazo-[1,2-a]-quinoline-2-carboxylic acid melting at ≈305° C. (decomp).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04279912 |
| Source dataset | uspto-grants-1981_07 |
| ORD ID | ord-f123739e905c4db1a170cb8e0e6028e8 |
| Source note | uspto-grants-1981_07 |