Sodium Hydroxide → HCID 70571317, compound

HRID 1277975Notes

Reaction equation

HRID 1277975 reaction equation
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([Cl:20])=[CH:7][C:8]3[N:9]2[CH:12]=[C:13]([C:15]([O:17]CC)=[O:16])[N:14]=3)=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C>[OH2:16].[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([Cl:20])=[CH:7][C:8]3[N:9]2[CH:12]=[C:13]([C:15]([OH:17])=[O:16])[N:14]=3)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 12763986Imidazo1,2-aquinoline-2-carboxylic acid, 8-bromo-5-chloro-, ethyl ester

Product 1

HCID 70571317HCID 70571317, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

400 mg of ethyl 8-bromo-5-chloroimidazo-[1,2-a]-quinoline-2-carboxylate were suspended in 200 ml of 50% aqueous ethanol and 4 ml of N sodium hydroxide solution were added. The mixture was heated on a steam bath for 1 hour and the resulting solution was filtered, then acidified with 4.4 ml of N hydrochloric acid. The mixture was cooled in ice to obtain cream needles of 8-bromo-5-chloroimidazo-[1,2-a]-quinoline-2-carboxylic acid monohydrate melting at >300° C.

Workup

  1. temperatureThe mixture was heated on a steam bath for 1 hour
  2. filtrationthe resulting solution was filtered
  3. temperatureThe mixture was cooled in ice

Sources & evidence

ORD record
ord-94866573b2e34364b162054fff8fd7e3
Source dataset
uspto-grants-1981_07
Patent number
US04279912

Reaction notes

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