N-Piperidinoethanol → HCID 131712295, compound

Participants

Reaction Conditions

Reaction Steps

0.85 g of imidazo-[1,2-a]-quinoline-2-carboxylic acid was dissolved in 25 ml of dry DMF and then 0.72 g of carbonyl diimidazole was added with stirring. The temperature was raised to 80° C. for 15 minutes and 0.57 g of (2-hydroxyethyl) piperidine was then added. The mixture was stirred at 100° C. for 3 hours and was cooled to room temperature and filtered. Then, 50 ml of water were added dropwise to the filtrate and the precipitate was filtered off, washed with water and dried under vacuum. This solid was crystallized from ethyl acetate/petroleum ether to obtain 2-piperidinoethyl imidazo-[1,2-a]-quinoline-2-carboxylate hemihydrate melting at 147°-150° C.

Provenance & Evidence