1,1,1,2-Tetrachloro-2,2-difluoroethane → 3,3-Dimethyl-4,6,6,7-tetrachloro-7,7-difluoroenanthic acid methyl ester

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Reaction Steps

37.5 g of 3,3-dimethyl-4-pentenoic acid methyl ester, 102 g of 1,1,1,2-tetrachloro-2,2-difluoroethane, 22 g of acetonitrile, 325 mg of FeCl3.6H2O, 255 mg of benzoin and 200 mg of dimethylamine hydrochloride were heated to 100°-120° C. in a 250 ml VA autoclave under 6 bars of nitrogen for 7 hours. Distillation of the mixture gave 3,3-dimethyl-4,6,6,7-tetrachloro-7,7-difluoroenanthic acid methyl ester of boiling point 129°-134° C./0.7-0.9 m bar. Refractive index: nD20 =1.4680. ##STR8##

Provenance & Evidence