Acetic Acid → HCID 20559413, compound

Participants

Reaction Steps

Sodium borohydride (165 mg) was added in portions over a period of 10 mins to a solution of 2-[2-[(5-formyl-2-furanylmethyl)thio]ethyl]-1H-isoindole-1,3(2H)-dione (5.0 g) in methanol (100 ml) at 0° C. After stirring for 45 mins, acetic acid (1 ml) was added and the mixture evaporated. Water (100 ml) was added and the solid that precipitated extracted into ethyl acetate (2×150 ml). The ethyl acetate extracts were dried (magnesium sulphate) and evaporated yielding an oil which solidified on trituration in light petroleum (b.p. 60°-80° C.). Crystallisation from methyl acetate-light petroleum (b.p. 60°-80° C.) afforded the title compound as a light, white solid (4.05 g) m.p. 82.5°-84° C.

Provenance & Evidence