反应详情

5.0 g of N,N-dipropyl-2-[[tetrahydro-5-[(2-propenyloxy)methyl]-2-furanyl]methoxy]acetamide (0.016 mole) is dissolved in 300 ml of methylene chloride and 3.20 g of m-chlorobenzoic acid (1 equivalent @ 85% tech) is added at room temperature. The mixture is then stirred at 30° for 72 hours under nitrogen. The precipitated m-chlorobenzoic acid is removed via filtration. The methylene chloride mixture is then washed with 2×200 ml portions of saturated potassium carbonate solution and dried over anhydrous sodium sulfate. The methylene chloride is removed in vacuo yielding 4.86 g (92%) of the above compound as a pale yellow liquid.

1. customThe precipitated m-chlorobenzoic acid is removed via filtration
2. washThe methylene chloride mixture is then washed with 2×200 ml portions of saturated potassium carbonate solution
3. dry with materialdried over anhydrous sodium sulfate
4. customThe methylene chloride is removed in vacuo