HCID 23452580, compound → HCID 13330059, compound

HRID 1278039Notes

Reaction equation

HRID 1278039 reaction equation
C([N:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[CH2:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22][CH3:23])[CH:15]=1)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[CH3:23][O:22][C:16]1[CH:15]=[C:14]([CH:19]=[CH:18][C:17]=1[O:20][CH3:21])[CH2:13][CH:9]1[CH2:10][CH2:11][CH2:12][NH:8]1

Participants

5

Reactant 2

HCID 23452580HCID 23452580, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 13330059HCID 13330059, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Hydrogenate 11.7 g of 1-benzyl-2-(3,4-dimethoxybenzyl)pyrrolidine in ethanol with 6.5 g of palladium/activated charcoal (10% strength)/hydrogen. Free the product from solvent and catalyst, and then distil it under a high vacuum. Purify via the picrate to obtain a yield of 3.2 g (38.5% of theory).

Workup

  1. customFree the product from solvent and catalyst, and then distil it under a high vacuum
  2. customPurify via the picrate
  3. customto obtain a yield of 3.2 g (38.5% of theory)

Sources & evidence

ORD record
ord-d6cd9f64da674020acfd82aadede7207
Source dataset
uspto-grants-1981_07
Patent number
US04279918

Reaction notes

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