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Ethyl 4-nitrophenylacetate → 2-(alpha-Ethoxycarbonyl-4-nitrobenzylidene)-1-methylpyrrolidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 4-nitrophenylacetate | HCID 79517 | — |
| 反応物 | 2,2-Diethoxy-1-methylpyrrolidine | HCID 297308 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | 2-(alpha-Ethoxycarbonyl-4-nitrobenzylidene)-1-methylpyrrolidine | HCID 54519793 | — |
反応手順
Boil 50 g of 4-nitrophenylacetic acid ethyl ester and 41.4 g of 2,2-diethoxy-1-methylpyrrolidine under reflux for 3 hours in 250 ml of benzene. Distil off the benzene before recrystallizing the resulting residue from diethyl ether/petroleum ether to obtain the title compound at a yield of 52.6 g (77% of theory) in the form of red crystals of m.p. 82° to 83°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04279918 |
| 出典データセット | uspto-grants-1981_07 |
| ORD ID | ord-be52418171e1411985dd9643aa0b5774 |
| 出典メモ | uspto-grants-1981_07 |