HCID 23452516, compound → HCID 23452567, compound

HRID 1278065Notes

Reaction equation

HRID 1278065 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][C:14]=1[OH:15])[CH2:5][CH:6]1[CH2:10][CH2:9][CH2:8][N:7]1[CH3:11]>C(OC(=O)C)(=O)C.N1C=CC=CC=1>[C:2]([O:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][C:14]=1[O:15][C:14](=[O:15])[CH3:13])[CH2:5][CH:6]1[CH2:10][CH2:9][CH2:8][N:7]1[CH3:11])(=[O:1])[CH3:3]

Participants

3

Reactant 1

HCID 23452516HCID 23452516, compound

Product 1

HCID 23452567HCID 23452567, compound

Reagents, catalysts & solvents 1

HCID 22348678Acetic anhydride pyridineSolvent

Procedure

Allow 3.25 g of 2-(3,4-dihydroxybenzyl)-1-methylpyrrolidine to stand for 24 hours in 30 ml of acetic anhydride/pyridine 1:1. Concentrate the resulting reaction mixture under a vacuum and distil off the residue to obtain 3.5 g (76% of theory) of the title compound in the form of a yellowish oil (b.p. 135° to 140° at 0.005 mm of Hg) which, on standing, solidifies to a crystalline mass of m.p. 44° to 45°.

Workup

  1. concentrationConcentrate
  2. customthe resulting reaction mixture under a vacuum
  3. customdistil off the residue

Sources & evidence

ORD record
ord-be487a577bd94b9e825ba592fdc89790
Source dataset
uspto-grants-1981_07
Patent number
US04279918

Reaction notes

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