反应详情

Dissolve 5.0 g of 1-acetyl-2-benzylpyrrolidine (at 0°) in 25 ml of concentrated sulfuric acid. At this temperature add (dropwise, with stirring) 20 ml of concentrated nitric acid to the thus-prepared solution. After warming the obtained reaction mixture to room temperature, pour it into 200 ml of ice water and extract it with diethyl ether. After drying over sodium sulfate, treat the extract with activated charcoal and then distil off the solvent to obtain the title compound as reddish oil.

1. additionAt this temperature add (dropwise,
2. temperatureAfter warming
3. customthe obtained reaction mixture to room temperature
4. extractionextract it with diethyl ether
5. dry with materialAfter drying over sodium sulfate
6. additiontreat the
7. extractionextract with activated charcoal
8. customdistil off the solvent