HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitrate → 5-(4-Aminobenzyl)-1-methylpyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitrate | HCID 943 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Benzylpyrrolidin-2-One | HCID 99881 | — |
| Reactant | 5-Benzyl-1-methylpyrrolidin-2-one | HCID 20062379 | — |
| Reactant | Sulfuric acid, mixt. with nitric acid | HCID 71777668 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 5-(4-Aminobenzyl)-1-methylpyrrolidin-2-one | HCID 23452598 | — |
Reaction Steps
Methylate 5-benzylpyrrolidin-2-one with methyl iodide in the presence of potassium carbonate in ethyl methyl ketone; nitrate the thus-obtained 5-benzyl-1-methylpyrrolidin-2-one with nitric acid/sulfuric acid, pour the resulting reaction product onto ice water, extract it with methylene chloride, evaporate solvent from the extract and hydrogenate the thus-obtained 1-methyl-5-(4-nitrobenzyl)pyrrolidin-2-one with platinum/hydrogen without further purification to obtain 5-(4-aminobenzyl)-1-methylpyrrolidin-2-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04279918 |
| Source dataset | uspto-grants-1981_07 |
| ORD ID | ord-56a611f10c1349b581a1012291d37a03 |
| Source note | uspto-grants-1981_07 |