Bicyclo(3.1.1)heptane-3-methanamine, 2,6,6-trimethyl- → alpha-Isocyanopropionic acid (+)-3-pinylmethylamide

Beteiligte Stoffe

Reaktionsschritte

A mixture of 5.7 g (50 mmoles) of methyl α-isocyanopropionate and 8.3 g (50 mmoles) of (+)-3-aminomethylpinane is stirred for 15 hours at room temperature, initially with slight cooling. After distilling off the resulting methanol in a high vacuum at 80° C., 11.6 g of crystalline α-isocyanopropionic acid (+)-3-pinylmethylamide of melting point 58°-59° C. remain. IR spectrum (KBr): 3,230 (N--H), 2,130 (N≡C), 1,670 cm-1 (C=O).

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