HCID 12870481, compound → HCID 12870414, compound

HRID 127810Notes

Reaction equation

HRID 127810 reaction equation
[CH2:1]([O:3][C:4](/[CH:6]=[CH:7]/[C:8]([N:11]1[CH:15]=[CH:14][N:13]=[CH:12]1)([CH3:10])[CH3:9])=[O:5])[CH3:2]>[Pd].C(O)C>[CH2:1]([O:3][C:4]([CH2:6][CH2:7][C:8]([N:11]1[CH:15]=[CH:14][N:13]=[CH:12]1)([CH3:10])[CH3:9])=[O:5])[CH3:2]

Participants

4

Reactant 1

HCID 12870481HCID 12870481, compound

Product 1

HCID 12870414HCID 12870414, compoundYield 95.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 0.59 g of the 2-propenyl compound (prepared as described in Reference Example 9), 0.30 g of 5% palladium on carbon and 6 ml of ethanol was stirred at room temperature for 1.5 hours under an atmosphere of hydrogen, and the catalyst was filtered off. After evaporation under reduced pressure, the residue was purified by column chromatography on silica gel using a mixture of chloroform and ethanol (99:1) as eluent to give 0.57 g of the title compound having the following physical characteristics:

Workup

  1. filtrationthe catalyst was filtered off
  2. customAfter evaporation under reduced pressure
  3. customthe residue was purified by column chromatography on silica gel using
  4. additiona mixture of chloroform and ethanol (99:1) as eluent

Sources & evidence

ORD record
ord-8bd026f8ca484e759d88f00e1026d07a
Source dataset
uspto-grants-1981_03
Patent number
US04256757

Reaction notes

Loading…