HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-[N-(4-methoxy-6-methylpyrimidin-2-yl)-N-methylaminocarbonyl]2,5-dichloro-N-methylbenzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-methoxy-N,6-dimethylpyrimidin-2-amine | HCID 1376672 | — |
| Reactant | N-[(2,5-dichlorophenyl)sulfonyl]-N-methylcarbamyl chloride | HCID 12875196 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-[N-(4-methoxy-6-methylpyrimidin-2-yl)-N-methylaminocarbonyl]2,5-dichloro-N-methylbenzenesulfonamide | HCID 12875197 | — |
Reaction Steps
To 3.0 g of N-[(2,5-dichlorophenyl)sulfonyl]-N-methylcarbamyl chloride in 50 ml of tetrahydrofuran containing 1.0 g of triethylamine is added 1.5 g of 2-methylamino-4-methoxy-6-methylpyrimidine. After stirring at reflux for several hours, the precipitated salts are filtered off and the filtrate is concentrated to yield N-[N-(4-methoxy-6-methylpyrimidin-2-yl)-N-methylaminocarbonyl]2,5-dichloro-N-methylbenzenesulfonamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04257802 |
| Source dataset | uspto-grants-1981_03 |
| ORD ID | ord-eefa421f49634a6a94061339eae9933b |
| Source note | uspto-grants-1981_03 |