2-Amino-5-bromopyridine → Benzamide, N-(((5-bromo-2-pyridinyl)amino)carbonyl)-2,6-difluoro-

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Reaction Steps

A 2 g. portion of 5-bromo-2-aminopyridine was reacted with 2.5 g. of 2,6-difluorobenzoyl isocyanate under nitrogen in 50 ml. of ethyl acetate. The reaction mixture was stirred for 3 days, and was then filtered. The solids were washed with dichloromethane, ethyl acetate and diethyl ether and dried under vacuum to obtain the desired product, m.p. 232°-235° C. The elemental analysis showed:

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