2-Amino-5-bromopyridine → 1-(2-Chloro-6-fluorobenzoyl)-3-(5-bromo-2-pyridinyl)urea

HRID 1278183Notes

Reaction equation

HRID 1278183 reaction equation
[Cl:1][C:2]1[CH:13]=[CH:12][CH:11]=[C:10]([F:14])[C:3]=1[C:4]([NH:6][C:7](Cl)=[O:8])=[O:5].[Br:15][C:16]1[CH:17]=[CH:18][C:19]([NH2:22])=[N:20][CH:21]=1>>[Cl:1][C:2]1[CH:13]=[CH:12][CH:11]=[C:10]([F:14])[C:3]=1[C:4]([NH:6][C:7]([NH:22][C:19]1[CH:18]=[CH:17][C:16]([Br:15])=[CH:21][N:20]=1)=[O:8])=[O:5]

Participants

3

Reactant 2

HCID 706222-Amino-5-bromopyridineHCID 537976672-Chloro-6-fluorobenzamidocarboxylic acid chloride

Product 1

HCID 130230741-(2-Chloro-6-fluorobenzoyl)-3-(5-bromo-2-pyridinyl)urea

Procedure

To a portion of 2-chloro-6-fluorobenzamidocarboxylic acid chloride dissolved in an organic solvent, a hydrogen halide acceptor is added, and a portion of 5-bromo-2-aminopyridine is added. After a period of stirring, the reaction mixture is washed with water and neutralized, and the product named in the heading is isolated as described in Example 12. The product is identical to that of Example 2 above.

Workup

  1. washthe reaction mixture is washed with water
  2. customis isolated

Sources & evidence

ORD record
ord-4ee9ed45a07440e784f577125e4f3d49
Source dataset
uspto-grants-1981_07
Patent number
US04281003

Reaction notes

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