2-Amino-5-bromopyridine → 1-(2-Chloro-6-fluorobenzoyl)-3-(5-bromo-2-pyridinyl)urea

HRID 1278187Notes

Reaction equation

HRID 1278187 reaction equation
[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[C:3]=1[C:4]([NH:6][C:7]([O:9]C1C=CC([N+]([O-])=O)=CC=1)=O)=[O:5].[Br:24][C:25]1[CH:26]=[CH:27][C:28]([NH2:31])=[N:29][CH:30]=1>>[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[C:3]=1[C:4]([NH:6][C:7]([NH:31][C:28]1[CH:27]=[CH:26][C:25]([Br:24])=[CH:30][N:29]=1)=[O:9])=[O:5]

Participants

3

Reactant 2

HCID 706222-Amino-5-bromopyridineHCID 570409802-Chloro-6-fluorobenzamidocarboxylic acid, 4-nitrophenyl ester

Product 1

HCID 130230741-(2-Chloro-6-fluorobenzoyl)-3-(5-bromo-2-pyridinyl)urea

Procedure

To a solution of 2-chloro-6-fluorobenzamidocarboxylic acid, 4-nitrophenyl ester, in an inert organic solvent is added 5-bromo-2-aminopyridine. The reaction mixture is stirred at an elevated temperature for a period of time, and is then evaporated to dryness under vacuum. The product named in the heading above, identical to the product of Example 2, is isolated and purified by recrystallization.

Workup

  1. customis then evaporated to dryness under vacuum
  2. customis isolated
  3. custompurified by recrystallization

Sources & evidence

ORD record
ord-f41619048b9f44fe984c3c1b1e1bfa8c
Source dataset
uspto-grants-1981_07
Patent number
US04281003

Reaction notes

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