反应详情

A mixture of 54.8 g of 2B and 200 ml of 98% formic acid was refluxed for one hour, cooled and poured into ice water. The resulting mixture was extracted with ether. The extract was washed, successively, with aqueous soidum bicarbonate and water, dried and the solvent was evaporated under reduced pressure. The residue, a syrup, crystallized from 1/5 v/v ether/hexane to give N-(4-isopropoxy-3-(trifluoromethyl)phenyl)formamide (2C), as a tan solid, mp: 80°-82° C.

1. temperaturewas refluxed for one hour
2. temperaturecooled
3. extractionThe resulting mixture was extracted with ether
4. washThe extract was washed
5. dry with materialsuccessively, with aqueous soidum bicarbonate and water, dried
6. customthe solvent was evaporated under reduced pressure
7. customThe residue, a syrup, crystallized from 1/5 v/v ether/hexane