Potassium Hydroxide → HCID 70577768, compound

HRID 1278192Notes

Reaction equation

C[O:2][C:3]([C:5]1[CH:10]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[CH:12]=2)[C:9]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[C:8]([CH3:23])[NH:7][N:6]=1)=[O:4].[OH-].[K+]>>[CH2:21]([O:20][C:18]([C:9]1[CH:10]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[CH:12]=2)[C:5]([C:3]([OH:4])=[O:2])=[N:6][NH:7][C:8]=1[CH3:23])=[O:19])[CH3:22]

Participants

Reactant 2

HCID 14797Potassium Hydroxide

HCID 70576671HCID 70576671, compound

Product 1

HCID 70577768HCID 70577768, compound

Procedure

0.1 mol of 4-(3-chlorophenyl)-1,4-dihydro-6-methyl-pyridazine-3,5-dicarboxylic acid 5-ethyl 3-methyl ester is saponified with 0.105 mol of KOH analogously to Example 28 to give 4-(3-chlorophenyl)-1,4-dihydro-6-methyl-pyridazine-3,5-dicarboxylic acid 5-ethyl ester. Melting point 182° C. (ethanol).

Sources & evidence

ORD record: ord-4c930e37b2b641498fa6309853d44108
Source dataset: uspto-grants-1981_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04280998

Reaction notes

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