1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one → ETHYL 7-(PYRIDIN-3-YL)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLATE

HRID 1278199Notes

Reaction equation

HRID 1278199 reaction equation
[NH2:1][C:2]1[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[CH:5][NH:4][N:3]=1.CN(C)[CH:14]=[CH:15][C:16]([C:18]1[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=1)=O>C(O)(=O)C>[CH2:10]([O:9][C:7]([C:6]1[CH:5]=[N:4][N:3]2[C:16]([C:18]3[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=3)=[CH:15][CH:14]=[N:1][C:2]=12)=[O:8])[CH3:11]

Participants

4

Reactant 2

HCID 5670331-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-oneHCID 178469928HCID 178469928, compound

Product 1

HCID 11196438ETHYL 7-(PYRIDIN-3-YL)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLATE

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

As for Example 2, 1.04 g. of 3-amino-4-carboethoxypyrazole is heated at reflux temperature for 16 hours with 1.18 g. of 3-dimethylamino-1-(3-pyridyl)-2-propen-1-one in 25 ml. of glacial acetic acid to give 1.30 g. of the product of the example as colorless needles, m.p. 170°-171° C.

Workup

  1. temperatureat reflux temperature for 16 hours with 1.18 g

Sources & evidence

ORD record
ord-eb5a3bed243c4ddea2c93acc06f34ded
Source dataset
uspto-grants-1981_07
Patent number
US04281000

Reaction notes

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