反应详情

A mixture of 60.7 g of 4-bromo-3-chloroaniline and 300 ml of 97% formic acid was refluxed for four hours. The resulting mixture was poured over ice and filtered. The solid was washed with water and recrystallized from 3/1 v/v ether/hexane to give N-(4-bromo-3-chlorophenyl)formamide (4A), as a tan solid, mp: 110°-113° C.

1. temperaturewas refluxed for four hours
2. additionThe resulting mixture was poured over ice
3. filtrationfiltered
4. washThe solid was washed with water
5. customrecrystallized from 3/1 v/v ether/hexane