Ethanol → HCID 21163089, compound

Participants

Reaction Steps

A mixture of 0.01 mole of ethyl 7-(3-pyridyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate and lithium aluminum hydride in ether is heated at reflux temperature for 8 hours. To the mixture is added (dropwise) ethanol and water. The ethereal layer is separated, then ethanol and anhydrous hydrochloric acid is added to it. The resulting mixture is refluxed for 8 hours and the solvent is removed. The residue is extracted with dichloromethane. The dichloromethane extract is passed through a column of hydrous magnesium silicate. The eluent is concentrated and diluted with hexane to give the product of the example.

Provenance & Evidence