N-bromobutanimide → HCID 12766270, compound

Participants

Reaction Steps

A mixture of 1.65 g. of 6-methyl-7-(3-pyridyl)pyrazolo[1,5-a]pyrimidine and 1.54 g. of N-bromosuccinimide in 50 ml. of dichloromethane is heated on a steam bath for 15 minutes. The mixture is poured into 100 ml. of ice cold 2.5 N sodium hydroxide. The dichloromethane layer is separated, dried over anhydrous sodium sulfate and passed through a column of hydrous magnesium silicate. The eluent is concentrated and hexane added to give 1.20 g. of the product of the example, m.p. 166°-168° C.

Provenance & Evidence