反应详情

A mixture of 1.90 g. of 3-dimethylamino-2-methyl-1-(3-pyridyl)-2-propen-1-one and 1.22 g. of 3-amino-5-methylpyrazole-4-carbonitrile in 25 ml. of glacial acetic acid is refluxed for 6 hours. The solvent is removed in vacuo and the residue partitioned between dichloromethane and saturated sodium bicarbonate solution. The dichloromethane layer is separated, dried over anhydrous sodium sulfate and passed through a column of hydrous magnesium silicate. The eluent is concentrated and hexane added to give 0.95 g. of the product of the example, m.p. 207°-209° C.

1. additionA mixture of 1.90 g
2. customThe solvent is removed in vacuo
3. customthe residue partitioned between dichloromethane and saturated sodium bicarbonate solution
4. customThe dichloromethane layer is separated
5. dry with materialdried over anhydrous sodium sulfate
6. concentrationThe eluent is concentrated
7. additionhexane added
8. customto give 0.95 g