反应详情

A mixture of 0.84 g. of 3-aminopyrazole and 1.90 g. of 3-dimethylamino-1-(6-methyl-2-pyridyl)-2-propen-1-one and 25. ml. of glacial acetic acid is heated on a steam bath for 4 hours. The solvent was removed under reduced pressure. The residue is dissolved in dichloromethane and the solution passed through a short column of hydrous magnesium silicate. The element is concentrated and diluted with hexane to give 1.15 g. of crystals, m.p. 126°-127° C.

1. additionA mixture of 0.84 g
2. customThe solvent was removed under reduced pressure
3. dissolutionThe residue is dissolved in dichloromethane
4. concentrationThe element is concentrated
5. additiondiluted with hexane
6. customto give 1.15 g