3-Dimethylamino-1-(6-methyl-2-pyridyl)-2-propen-1-one → 3-Methyl-7-(6-methyl-2-pyridyl)pyrazolo[1,5-a]pyrimidine

HRID 1278239Notes

Reaction equation

HRID 1278239 reaction equation
C[N:2]([CH3:14])[CH:3]=[CH:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([CH3:13])[N:8]=1)=O.N[C:16]1[C:20](C)=[CH:19][NH:18][N:17]=1>CC(OCC1C2C(=CC=CC=2)C(COC(C)=O)=C2C=1C=CC=C2)=O>[CH3:19][C:20]1[CH:16]=[N:17][N:18]2[C:5]([C:7]3[CH:12]=[CH:11][CH:10]=[C:9]([CH3:13])[N:8]=3)=[CH:4][CH:3]=[N:2][C:14]=12

Participants

4

Reactant 2

HCID 538801933-Dimethylamino-1-(6-methyl-2-pyridyl)-2-propen-1-oneHCID 178430915HCID 178430915, compound

Product 1

HCID 211630913-Methyl-7-(6-methyl-2-pyridyl)pyrazolo[1,5-a]pyrimidine

Reagents, catalysts & solvents 1

HCID 613145Acetic acid 10-acetoxymethyl-anthracen-9-ylmethyl esterSolvent

Procedure

As for example 53, a mixture of 3-dimethylamino-1-(6-methyl-2-pyridyl)-2-propen-1-one and 3-amino-4-methylpyrazole in glacial acetic is refluxed for 4 hours to give the product of the example.

Workup

  1. temperatureis refluxed for 4 hours
  2. customto give the product of the example

Sources & evidence

ORD record
ord-a5d0b82d346c42df88be7cc348217d64
Source dataset
uspto-grants-1981_07
Patent number
US04281000

Reaction notes

Loading…