3-Dimethylamino-1-(4-methyl-2-pyridyl)-2-propen-1-one → 7-(4-Methyl-2-pyridyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile

HRID 1278242Notes

Reaction equation

HRID 1278242 reaction equation
C[N:2]([CH3:14])[CH:3]=[CH:4][C:5]([C:7]1[CH:12]=[C:11]([CH3:13])[CH:10]=[CH:9][N:8]=1)=O.N[C:16]1[C:20]([C:21]#[N:22])=C[NH:18][N:17]=1>C(O)(=O)C>[CH3:13][C:11]1[CH:10]=[CH:9][N:8]=[C:7]([C:5]2[N:18]3[N:17]=[CH:16][C:20]([C:21]#[N:22])=[C:14]3[N:2]=[CH:3][CH:4]=2)[CH:12]=1

Participants

4

Reactant 2

HCID 541170263-Dimethylamino-1-(4-methyl-2-pyridyl)-2-propen-1-oneHCID 178510443HCID 178510443, compound

Product 1

HCID 211630957-(4-Methyl-2-pyridyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 0.01 mole of 3-dimethylamino-1-(4-methyl-2-pyridyl)-2-propen-1-one and 0.01 mole of 3-aminopyrazole-4-carbonitrile in glacial acetic acid is refluxed for 8 hours and worked up as for Example 53 to give the product of the example.

Workup

  1. temperatureis refluxed for 8 hours
  2. customto give the product of the example

Sources & evidence

ORD record
ord-b78bb6356be346d5b4e5639005af8460
Source dataset
uspto-grants-1981_07
Patent number
US04281000

Reaction notes

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