2-Propen-1-one, 3-(dimethylamino)-1-(4-pyridinyl)- → HCID 12766264, compound

HRID 1278246Notes

Reaction equation

HRID 1278246 reaction equation
C[N:2]([CH3:13])[CH:3]=[CH:4][C:5]([C:7]1[CH:12]=[CH:11][N:10]=[CH:9][CH:8]=1)=O.N[C:15]1[C:19]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=C[NH:17][N:16]=1>C(O)(=O)C>[N:10]1[CH:9]=[CH:8][C:7]([C:5]2[N:17]3[N:16]=[CH:15][C:19]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[C:13]3[N:2]=[CH:3][CH:4]=2)=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 7145312-Propen-1-one, 3-(dimethylamino)-1-(4-pyridinyl)-HCID 178469928HCID 178469928, compound

Product 1

HCID 12766264HCID 12766264, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 3.52 g. of 3-dimethylamino-1-(4-pyridyl)-2-propen-1-one and 3.10 g. of ethyl 3-aminopyrazole-4-carboxylate in 50 ml. of glacial acetic acid is refluxed for 15 hours. The solvent is removed and the residue worked up as for Example 53 to give 3.0 g. of crystals, m.p. 209°-210° C.

Workup

  1. additionA mixture of 3.52 g
  2. customThe solvent is removed
  3. customto give 3.0 g

Sources & evidence

ORD record
ord-9cf5598f67a0492f98b3e5dc565e0fa7
Source dataset
uspto-grants-1981_07
Patent number
US04281000

Reaction notes

Loading…