Hydrochloric Acid → 74697-34-0

Participants

Reaction Steps

55.3 Grams of 3-chloro-4,4'-dimethoxybenzophenone, 65.1 g of potassium cyanide, 96 g of ammonium carbonate and 94.8 g of ammonium hydrogencarbonate were charged in an autoclave together with 500 ml. of formamide and 100 ml. of water and the whole was heated at 120° C. with stirring for 48 hours. The reaction liquid was made acidic with concentrated hydrochloric acid, mixed with water and allowed to stand in a cool place overnight. The precipitates thus formed were washed with water and filtered out. The filtration residue was dissolved in 80% ethanol-water under heating, decolorized with active carbon and recrystallized from ethanol-chloroform to obtain 40.0 g of 5-(3-chloro-4-methoxyphenyl)-5-(4-methoxyphenyl)hydantoin in the form of white crystals.

Provenance & Evidence