Benzene → HCID 15078343, compound

Participants

Reaction Steps

A solution of 7-benzyloxy-4-oxo-8-n-propyl-4H-1-benzopyran-2-carboxaldehyde (1.0 g) in dry benzene (30 ml) was added to a stirred solution of carbethoxymethylene-triphenylphosphorane (1.1 g) in dry benzene (50 ml). After 1 hour the solvent was evaporated and the remaining white solid was extracted several times with ether. The combined and concentrated ether washings were chromatographed over silica gel (100 g). Elution with ether afforded a white solid which was crystallised from ether to yield trans ethyl 3-(7-benzyloxy-4-oxo-8-n-propyl-4H-1-benzopyran-2-yl)acrylate (0.45 g) mp 140° C., a compound of the invention.

Provenance & Evidence