Carbon Tetrachloride → HCID 21163137, compound

Participants

Reaction Steps

A solution of trans-ethyl 3-[7-[3-(4-acetyl-3-hydroxy-2-n-propylphenoxy)-2-hydroxypropyloxy]-4-oxo-8-n-propyl-4H-1-benzopyran-2-yl]acrylate (1.56 g) and sodium hydrogen carbonate (1.56 g) in aqueous ethanol was refluxed for 1 hour. Ethanol was removed by distillation and the residual aqueous solution cooled. Acidification afforded a gum which solidified on prolonged treatment with refluxing carbon tetrachloride. Crystallisation from acetone-carbon tetrachloride yielded trans-3[7-[3-(4-acetyl-3-hydroxy-2-n-propylphenoxy)-2-hydroxypropyloxy]-4-oxo-8-n-propyl-4H-1-benzopyran-2-yl]acrylic acid (0.58 g) mp 101°-103° C.

Provenance & Evidence