HCID 86737893, compound → HCID 21163157, compound

Participants

Reaction Steps

trans-Ethyl 3-[7-[3-(4-acetyl-3-hydroxy-2-n-propyl phenoxy)-2-hydroxypropyloxy]-4-oxo-8-n-propyl-4H-1-benzopyran-2-yl]acrylate (1.2 g) in dioxan was hydrogenated, over a palladium-charcoal catalyst, at atmospheric pressure and ambient temperature. The catalyst was removed by filtration and the concentrated filtrate chromatographed over silica-gel (60 g). Elution with ether afforded a white solid which was crystallised from etherpetrol (40°-60°) to yield ethyl 3-[7-[3-(4-acetyl-3-hydroxy-2-n-propylphenoxy)-2-hydroxypropyloxy]-4-oxo-8-n-propyl-4H-1-benzopyran-2-yl]propionate (0.79 g), mp 137°-138° C.

Provenance & Evidence