Sodium Hydroxide → HCID 21163152, compound

Participants

Reaction Steps

To sodium hydroxide (0.6 g) in ethanol (200 ml) was added (4-acetyl-2-n-butyl-3-hydroxyphenoxy)methyloxiran (6 g) and ethyl 3-(7-hydroxy-4-oxo-8-propyl-4H-1-benzopyran-2-yl)propionate (4.56 g). The mixture was refluxed for 6 hours, evaporated to 1/3 volume and acidified. Extraction with ethyl acetate and subsequent washing with 10% sodium hydroxide solution, and water, and evaporation gave a red oil which was chromatographed on silica with chloroform:ethyl acetate (12:1) mixture to yield a solid. Recrystallisation from ethyl acetate/cyclohexane mixture afforded the title ester as buff micro needles (2.3 g), mp 118°-118.5°.

Provenance & Evidence