Malonic Acid → HCID 54019879, compound

HRID 1278273Notes

Reaction equation

HRID 1278273 reaction equation
[CH2:1]([O:8][C:9]1[CH:21]=[CH:20][C:12]2[C:13](=[O:19])[CH:14]=[C:15](C=O)[O:16][C:11]=2[C:10]=1[CH2:22][CH2:23][CH3:24])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:25](O)(=O)[CH2:26][C:27]([OH:29])=[O:28]>N1C=CC=CC=1>[CH2:1]([O:8][C:9]1[CH:21]=[CH:20][C:12]2[C:13](=[O:19])[CH:14]=[C:15]([CH:25]=[CH:26][C:27]([OH:29])=[O:28])[O:16][C:11]=2[C:10]=1[CH2:22][CH2:23][CH3:24])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 867Malonic AcidHCID 21163153HCID 21163153, compound

Product 1

HCID 54019879HCID 54019879, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

7-Benzyloxy-4-oxo-8-propyl-4H-1-benzopyran-2-carboxaldehyde (3.2 g), from Example 1(c) and malonic acid (1.1 g) were heated in pyridine (15 ml) at 100° C. until gas evolution ceased. The mixture was then evaporated and the residue was extracted with sodium bicarbonate. Acidification gave the title acid. The same acid was also prepared by hydrolysis of the product of Example 1(d).

Workup

  1. customThe mixture was then evaporated
  2. extractionthe residue was extracted with sodium bicarbonate

Sources & evidence

ORD record
ord-a44d917d49b44e7c89aebf510a8752b7
Source dataset
uspto-grants-1981_07
Patent number
US04281008

Reaction notes

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