HCID 12565692, compound → 5-Indanacetic acid, 3-oxo-

HRID 1278275Notes

Reaction equation

HRID 1278275 reaction equation
[C:1]([CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][C:13]([OH:15])=[O:14])=[CH:8][CH:7]=1)([OH:3])=O>O>[O:3]=[C:1]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([CH2:12][C:13]([OH:15])=[O:14])[CH:10]=2)[CH2:5][CH2:4]1

Participants

3

Reactant 1

HCID 12565692HCID 12565692, compound

Product 1

HCID 30549485-Indanacetic acid, 3-oxo-

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Polyphosphoric acid (1 kg) was stirred and heated to 95°-100° C. and 4-(2-Carboxyethyl)phenylacetic acid (100 g, 0.48 mol) added over 10 minutes. The mixture was stirred for 0.5 hours and poured into ice and H2O; the product was continuously extracted with CHCl3, and recrystallised from benzene to give the title product, m.p. 133°-5° C.

Workup

  1. temperatureheated to 95°-100° C.
  2. extractionthe product was continuously extracted with CHCl3
  3. customrecrystallised from benzene

Sources & evidence

ORD record
ord-990dcfcc3ee74ee2b7de5d13a7a17531
Source dataset
uspto-grants-1981_07
Patent number
US04281017

Reaction notes

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