HCID 12565700, compound → [4-(3-Oxo-2,3-dihydro-1H-inden-1-yl)phenyl]acetic acid

HRID 1278278Notes

Reaction equation

HRID 1278278 reaction equation
C1([CH:7]([C:12]2[CH:17]=[CH:16][C:15]([CH2:18][C:19]([OH:21])=[O:20])=[CH:14][CH:13]=2)[CH2:8][C:9](O)=[O:10])C=CC=CC=1>O>[O:10]=[C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:7]([C:12]2[CH:13]=[CH:14][C:15]([CH2:18][C:19]([OH:21])=[O:20])=[CH:16][CH:17]=2)[CH2:8]1

Participants

3

Reactant 1

HCID 12565700HCID 12565700, compound

Product 1

HCID 51431[4-(3-Oxo-2,3-dihydro-1H-inden-1-yl)phenyl]acetic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Polyphosphoric acid (1 kg) was stirred and heated to 95°-100° C. and β-phenyl-p-(carboxymethyl)-hydrocinnamic acid (0.48 mol) added over 10 minutes. The mixture was stirred for 1/2 hour and poured into ice and H2O; the title product was continuously extracted with CHCl3 and recrystallised from ether, m.p. 151° C.

Workup

  1. temperatureheated to 95°-100° C.
  2. extractionthe title product was continuously extracted with CHCl3
  3. customrecrystallised from ether, m.p. 151° C.

Sources & evidence

ORD record
ord-ece42d9861c040abb4514f1d1cb3497f
Source dataset
uspto-grants-1981_07
Patent number
US04281017

Reaction notes

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