Benzoic acid, 5-chloro-2-hydroxy-, methyl ester → HCID 13076865, compound

270 ml of a solution of cyclohexyl magnesium bromide titrating 1.3 M/liter in ether were added dropwise with stirring at room temperature to a mixture of 18.7 g of methyl 5-chloro-2-hydroxy-benzoate in 150 ml of ether and the ether was distilled while replacing it with 270 ml of benzene. The mixture was then refluxed for 20 hours and was cooled and poured into a mixture of 500 g of ice and 300 ml of an aqueous solution containing 105 g of ammonium chloride. The mixture was extracted once with 250 ml of ether, twice with 150 ml of ether and 3 times with 100 ml of methylene chloride. The organic phases were washed 3 times with 100 ml of water, were dried over magnesium sulfate in the presence of activated carbon and was evaporated to dryness. The residue was taken up in 50 ml of cyclohexane and the mixture was vacuum filtered. The product was dried to obtain 20,200 g of 5-chloro-α,α-dicyclohexyl-2-hydroxybenzene-methanol melting at 230° C.

1. distillationthe ether was distilled
2. temperatureThe mixture was then refluxed for 20 hours
3. temperaturewas cooled
4. additionpoured into a mixture of 500 g of ice and 300 ml of an aqueous solution
5. additioncontaining 105 g of ammonium chloride
6. extractionThe mixture was extracted once with 250 ml of ether, twice with 150 ml of ether and 3 times with 100 ml of methylene chloride
7. washThe organic phases were washed 3 times with 100 ml of water
8. dry with materialwere dried over magnesium sulfate in the presence of activated carbon
9. customwas evaporated to dryness
10. filtrationfiltered
11. customThe product was dried

ORD record

ord-85170d1f4dd54ad097471bfe94c958d8

Source dataset

uspto-grants-1981_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04281012