Hydrochloric Acid → HCID 13076858, compound

Participants

Reaction Steps

360 ml of an ether solution titrating 1 M/liter of allyl magnesium bromide were added dropwise with stirring to a mixture of 40 g of 2-hydroxy-5-chloro-benzophenone and 400 ml of anhydrous ether and the suspension was iced and stirred at room temperature for 16 hours. 180 ml of 2 N hydrochloric acid were added to the mixture and the decanted organic phase was washed with water, dried over mangesium sulfate and evaporated to dryness under reduced pressure. The oil residue was chromatographed over silica gel and was eluted with methylene chloride to obtain 18.9 g of 5-chloro-2-hydroxy-α-(2-propenyl)-α-phenyl-benzene-methanol.

Provenance & Evidence