Hydrochloric Acid → HCID 13076850, compound

Participants

Reaction Steps

310 ml of an ether solution titrating 0.76 M/liter of phenyl magnesium bromide were added over 1 hour to a mixture of 23.4 g of the product of Step A and 230 ml of anhydrous ether and the mixture was stirred for 16 hours at room temperature and was poured over ice. The mixture was acidified with 200 ml of 2 N hydrochloric acid and was extracted 3 times with 250 ml of ether. The organic phase was washed 3 times with 100 ml of water, dried over magnesium sulfate and evaporated to dryness under reduced pressure. The residue was taken up in 120 ml of petroleum ether (b.p.=60° to 80° C.) and the mixture was vacuum filtered. The product was dried to obtain 22.55 g of 5-cyclohexyl-2-hydroxy-α-methyl-α-phenyl-benzene-methanol melting at 119° C.

Provenance & Evidence