HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 1-(Ethoxycarbonyl)ethyl 4-(allylamino)phenylacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Ethyl 2-[(4-methylbenzenesulfonyl)oxy]propanoate | HCID 562846 | — |
| Reactant | Sodium 4-(allylamino)phenylacetate | HCID 23720721 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-(Ethoxycarbonyl)ethyl 4-(allylamino)phenylacetate | HCID 21163487 | — |
Reaction Steps
To a warm mixture of 7 g. sodium 4-(allylamino)phenylacetate in 100 ml. ethanol is added 4.7 g. ethyl 2-tosyloxypropionate. After 17 hours at reflux, the cooled solution is diluted with an equal volume of water and the resultant precipitate is filtered. After washing with cold ethanol and drying, the product is crystallized from acetonitrile to yield 1-(ethoxycarbonyl)ethyl 4-(allylamino)phenylacetate as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04281019 |
| Source dataset | uspto-grants-1981_07 |
| ORD ID | ord-bcb0e3fec60c4029b9726906323c9546 |
| Source note | uspto-grants-1981_07 |