Diethyl acetylenedicarboxylate → HCID 12899659, compound

Participants

Reaction Steps

8.5 g of 2-amino-5-pyrrolidino-1,3,4-thiadiazole were added to 300 ml of ethanol and mixed with 8.5 g of diethyl acetylenedicarboxylate. On heating for 10 to 20 minutes to about 50° to 60° C. a clear solution was obtained which after standing overnight at room temperature was evaporated in vacuo to dryness. The residue was triturated with a small amount of cold ethyl acetate, filtered off, washed with ether and then dried. 8.4 g (57.1% of the theoretical yield) of ethyl 2-pyrrolidino-7H-1,3,4-thiadiazolo-[3,2-a]pyrimidin-7-one-5-carboxylate were thus obtained.

Provenance & Evidence