HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl acetylenedicarboxylate → ethyl 2-piperidino-7H-1,3,4-thiadiazolo-[3,2-a]-pyrimidin-7-one-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl acetylenedicarboxylate | HCID 69803 | — |
| Reactant | 5-Piperidin-1-yl-1,3,4-thiadiazol-2-amine | HCID 1500010 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | ethyl 2-piperidino-7H-1,3,4-thiadiazolo-[3,2-a]-pyrimidin-7-one-5-carboxylate | HCID 12899660 | — |
Reaction Steps
The procedure used was as described in Example 5. However, there were used 9.2 g of 2-amino-5-piperidino-1,3,4-thiadiazole, 8.5 g of diethyl acetylenedicarboxylate and 200 ml of ethanol. Thus 9.8 g (63.7% of the theoretical yield) of ethyl 2-piperidino-7H-1,3,4-thiadiazolo-[3,2-a]-pyrimidin-7-one-5-carboxylate, melting at 125° to 127° C., were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04281120 |
| Source dataset | uspto-grants-1981_07 |
| ORD ID | ord-a88212953d824c88aa45b93e3d6abcb0 |
| Source note | uspto-grants-1981_07 |