Diethyl acetylenedicarboxylate → HCID 21163772, compound

HRID 1278326Notes

Reaction equation

HRID 1278326 reaction equation
[NH2:1][C:2]1[S:3][C:4]([N:7]([CH2:11][CH2:12][CH3:13])[CH2:8][CH2:9][CH3:10])=[N:5][N:6]=1.[C:14]([C:21](OCC)=[O:22])#[C:15][C:16]([O:18][CH2:19][CH3:20])=[O:17]>C(O)C>[CH2:8]([N:7]([CH2:11][CH2:12][CH3:13])[C:4]1[S:3][C:2]2=[N:1][C:21](=[O:22])[CH:14]=[C:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[N:6]2[N:5]=1)[CH2:9][CH3:10]

Participants

4

Reactant 2

HCID 69803Diethyl acetylenedicarboxylateHCID 12899674N2,N2-Dipropyl-1,3,4-thiadiazole-2,5-diamine

Product 1

HCID 21163772HCID 21163772, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The procedure used was as in Example 5. However, there were reacted 10 g of 2-amino-5-[di-(n-propyl)amino]-1,3,4-thiadiazole and 8.5 g of diethyl acetylenedicarboxylate in the presence of 200 ml of ethanol to give 10.2 g (63% of the theoretical yield) of ethyl 2-[di-(n-propyl)amino]-7H-1,3,4-thiadiazolo-[3,2-a]-pyrimidin-7-one-5-carboxylate, melting at 95°-97° C.

Workup

  1. customto give 10.2 g (63% of the

Sources & evidence

ORD record
ord-a1dbf6b4e6f6460f8feca0fa1320280c
Source dataset
uspto-grants-1981_07
Patent number
US04281120

Reaction notes

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