Diethyl acetylenedicarboxylate → HCID 21163773, compound

HRID 1278327Notes

Reaction equation

HRID 1278327 reaction equation
[NH2:1][C:2]1[S:3][C:4]([N:7]([CH:11]([CH3:13])[CH3:12])[CH:8]([CH3:10])[CH3:9])=[N:5][N:6]=1.[C:14]([C:21](OCC)=[O:22])#[C:15][C:16]([O:18][CH2:19][CH3:20])=[O:17]>C(O)C>[CH:8]([N:7]([CH:11]([CH3:13])[CH3:12])[C:4]1[S:3][C:2]2=[N:1][C:21](=[O:22])[CH:14]=[C:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[N:6]2[N:5]=1)([CH3:9])[CH3:10]

Participants

4

Reactant 2

HCID 69803Diethyl acetylenedicarboxylateHCID 7653782-amino-5-diisopropylamino-1,3,4-thiadiazole

Product 1

HCID 21163773HCID 21163773, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following the procedure described in Example 5, 4.9 g of 2-amino-5-[di-(isopropyl)-amino]-1,3,4-thiadiazole were reacted with 4.2 g of diethyl acetylenedicarboxylate in the presence of 100 ml of ethanol. The ethyl 2-[di-(isopropyl)-amino]-7H-1,3,4-thiadiazolo-[3,2-a]-pyrimidin 7-one-5-carboxylate obtained was recrystallized from ethyl acetate.

Sources & evidence

ORD record
ord-5423832e92db4afa82a6c9bbed24524c
Source dataset
uspto-grants-1981_07
Patent number
US04281120

Reaction notes

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