HCID 70565405, compound → HCID 86737616, compound

Participants

Reaction Steps

In 25 g of hydrochloric acid-dioxane solution (110 mg HCl/g) was dissolved 13.2 g of the above ester, and the solution was stirred at room temperature for 1.5 hrs. The reaction mixture was evaporated under reduced pressure to dryness, and anhydrous diethyl ether was added to the residue. The resulting mixture was allowed to stand for 24 hrs, and the colorless powders thus precipitated were collected to obtain 11.0 g (yield 95%) of Nε -benzyloxycarbonyl-L-lysine 1-naphthyl ester hydrochloride, m.p. 80°-82° C.

Provenance & Evidence