HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Ethyl 4-(2-sulfoethylamino)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Benzocaine | HCID 2337 | — |
| Reactant | 2-Bromoethanesulfonic acid, sodium salt | HCID 23666797 | — |
| Solvent | Hexamethylphosphoramide | HCID 12679 | — |
| Product | Ethyl 4-(2-sulfoethylamino)benzoate | HCID 21163340 | — |
Reaction Steps
A solution of 4.1 g. of sodium 2-bromoethanesulfonate and 7.9 g. of ethyl 4-aminobenzoate in 110 ml. of hexamethylphosphoramide is stirred at 125° for 18 hours and then poured into dilute hydrochloric acid. The solid is collected by filtration, dried and recrystallized from acetonitrile to yield ethyl 4-(2-sulfoethylamino)benzoate as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04281018 |
| Source dataset | uspto-grants-1981_07 |
| ORD ID | ord-ffb7f0e640a94638adcfcb5c26f44b28 |
| Source note | uspto-grants-1981_07 |