2,5-Dimethylphenol → HCID 23451686, compound

Participants

Reaction Conditions

Reaction Steps

2,5-Dimethylphenol (9.7 g, 0.08 mol) was added to a solution of sodium hydroxide (3.2 g, 0.08 mol) and sodium acetate (3.3 g, 0.04 mol) in distilled water (50 mL). The mixture was cooled to 15° C. and 2-isopropylidene-1,4-dichlorobutane (15 g, 0.09 mol) was added over 1 hour under nitrogen. After stirring at room temperature for 6 hours, the reaction mixture was extracted with ether. The ether extracts were washed with 10% sodium hydroxide, water, and dried (Na2SO4). Concentration gave 18.5 g of crude material consisting of mainly the alkylated phenol having the structure: ##STR38## A sample purified by column chromatography (silica gel) had the following spectral characteristics:

Provenance & Evidence